An ARS element inhibits DNA replication through a SIR2-dependent mechanism.

@article{Crampton2008AnAE,
  title={An ARS element inhibits DNA replication through a SIR2-dependent mechanism.},
  author={Amber Crampton and Fujung Chang and Donald L Pappas and Ryan L. Frisch and Michael Weinreich},
  journal={Molecular cell},
  year={2008},
  volume={30 2},
  pages={156-66}
}
During G1 phase, a prereplicative complex (pre-RC) that determines where DNA synthesis initiates forms at origins. The Sir2p histone deacetylase inhibits pre-RC assembly at a subset of origins, suggesting that Sir2p inhibits DNA replication through a unique aspect of origin structure. Here, we identified five SIR2-sensitive origins on chromosomes III and VI. Linker scan analysis of two origins indicated that they share a common organization, including an inhibitory sequence positioned 3' to the… CONTINUE READING
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