An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease.

@article{Lescai2011AnAH,
  title={An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease.},
  author={F Lescai and Andrea Maria Chiamenti and Alessandra Codemo and Chiara Pirazzini and Giuseppe Roberto D'Agostino and Cristina Ruaro and Roberta Ghidoni and Luisa Benussi and Daniela Galimberti and Federica Esposito and Francesca Marchegiani and Maurizio Cardelli and Fabiola Olivieri and Benedetta Nacmias and Sandro Sorbi and Fabrizio Tagliavini and D Albani and Filippo Martinelli Boneschi and Giuliano Binetti and Aurelia Santoro and Gianluigi Forloni and Elio Scarpini and Gaetano Crepaldi and Carlo Gabelli and Claudio Franceschi},
  journal={Journal of Alzheimer's disease : JAD},
  year={2011},
  volume={24 2},
  pages={235-45}
}
This paper addresses a tenet of the literature on APOE, i.e., the relationship between the effects of the ε4, one of the established genetic risk factor for Alzheimer's disease (AD), and its expression levels as determined by APOE promoter polymorphisms. Five polymorphisms (-491 rs449647, -427 rs769446, -219 rs405509, and ε rs429358-rs7412) were studied in 1308 AD patients and 1082 control individuals from the Central-Northern Italy. Major findings of the present study are the following: 1) the… CONTINUE READING

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