An AP Endonuclease 1–DNA Polymerase β Complex: Theoretical Prediction of Interacting Surfaces


Abasic (AP) sites in DNA arise through both endogenous and exogenous mechanisms. Since AP sites can prevent replication and transcription, the cell contains systems for their identification and repair. AP endonuclease (APEX1) cleaves the phosphodiester backbone 5' to the AP site. The cleavage, a key step in the base excision repair pathway, is followed by… (More)
DOI: 10.1371/journal.pcbi.1000066


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