An AFM/rotaxane molecular reading head for sequence-dependent DNA structures.

Abstract

DNA secondary structure may prove to be a significant obstacle both for enzymes that process DNA through an orifice and for the passage of DNA through nanopores proposed for some novel sequencing schemes. A nanomechanical molecular "tape reader" is assembled by threading a nanopore over DNA and pulling it using an atomic force microscope. Its formation is… (More)
DOI: 10.1002/smll.200800233

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