An ADP-ribosyltransferase Alt of bacteriophage T4 negatively regulates the Escherichia coli MazF toxin of a toxin-antitoxin module.

@article{Alawneh2016AnAA,
  title={An ADP-ribosyltransferase Alt of bacteriophage T4 negatively regulates the Escherichia coli MazF toxin of a toxin-antitoxin module.},
  author={Abdulraheem M Alawneh and Dan Qi and Tetsuro Yonesaki and Yuichi Otsuka},
  journal={Molecular microbiology},
  year={2016},
  volume={99 1},
  pages={188-98}
}
Prokaryotic toxin-antitoxin (TA) systems are linked to many roles in cell physiology, such as plasmid maintenance, stress response, persistence and protection from phage infection, and the activities of toxins are tightly regulated. Here, we describe a novel regulatory mechanism for a toxin of Escherichia coli TA systems. The MazF toxin of MazE-MazF, which is one of the best characterized type II TA systems, was modified immediately after infection with bacteriophage T4. Mass spectrometry… CONTINUE READING
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