An 8-week multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression.

@article{Schneider2003An8M,
  title={An 8-week multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression.},
  author={Lon S Schneider and James Craig Nelson and Cathryn M. Clary and Paul A. Newhouse and K. Ranga R. Krishnan and Thomas M. Shiovitz and Karen L Weihs},
  journal={The American journal of psychiatry},
  year={2003},
  volume={160 7},
  pages={
          1277-85
        }
}
OBJECTIVE There have been few placebo-controlled trials of selective serotonin reuptake inhibitors for depressed elderly patients. This placebo-controlled study of sertraline was designed to confirm the results of non-placebo-controlled trials. METHOD The subjects were outpatients age 60 years or older who had a DSM-IV diagnosis of major depressive disorder and a total score on the 17-item Hamilton Depression Rating Scale of 18 or higher. The patients were randomly assigned to 8 weeks of… 

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References

SHOWING 1-10 OF 35 REFERENCES
A double-blind comparison of sertraline and fluoxetine in depressed elderly outpatients.
TLDR
Data indicate that both drugs are effective antidepressants for the treatment of depressed elderly outpatients and differences in cognitive performance effects deserve further investigation.
A Double-Blind, Placebo-Controlled Clinical Trial of Fluoxetine in Geriatric Patients With Major Depression
TLDR
Fluoxetine, at a conventional 20-mg dose, was both safe and effective relative to placebo in this special population of outpatients over age 60, corroborate that major depression in an older population is responsive to antidepressant pharmacotherapy.
Double-blind, multicenter comparison of sertraline and amitriptyline in elderly depressed patients.
TLDR
Sertraline was associated with a statistically lower frequency of somnolence, dry mouth, constipation, ataxia, and pain and a higher frequency of nausea, anorexia, diarrhea/loose stools, and insomnia; thus, anticholinergic effects were less common and gastrointestinal effects were more common with sertralines than with amitriptyline.
Comparison of sertraline and nortriptyline in the treatment of major depressive disorder in late life.
TLDR
Primary efficacy measures showed sertraline and nortriptyline to be similarly effective and secondary efficacy measures (posttreatment measures of cognitive function, memory, and quality of life) revealed a significant advantage for sERTraline treatment.
A double‐blind, multicentre study of paroxetine versus clomipramine in depressed elderly patients
TLDR
Assessment of tolerability was based on reports of adverse experiences (AER), both spontaneously reported and elicited in response to a side-effect symptom checklist, physical examination, ECG, vital signs, and laboratory investigations.
Treatment of major depression with nortriptyline and paroxetine in patients with ischemic heart disease.
TLDR
Paroxetine was better tolerated than nortriptyline and less likely to produce cardiovascular side effects and 90% of patients improved at least 50%, and of these, 90% met the criteria for remission.
Comparison of the tolerability and efficacy of citalopram and amitriptyline in elderly depressed patients treated in general practice
TLDR
It was concluded that citalopram is as effective an antidepressant as amitriptyline in the treatment of the depressed elderly because of its low incidence and low magnitude of side effects.
Double-blind comparative trials of fluoxetine and doxepin in geriatric patients with major depressive disorder.
TLDR
Fluoxetine, which lacks anticholinergic effects and is nonsedating, was well-tolerated by most patients and had fewer total side effects than doxepin.
Use of serotonin selective reuptake inhibitors in geriatric depression.
  • P. Newhouse
  • Medicine, Psychology
    The Journal of clinical psychiatry
  • 1996
TLDR
Data from controlled studies of the treatment of geriatric depression for all four available SSRIs in the United States are reviewed, particularly with reference to clinically relevant differences in pharmacokinetics and hepatic isoenzyme inhibition.
Fluoxetine compared with amitriptyline in elderly depression: a controlled clinical trial.
TLDR
Both groups showed a significant amelioration at the end point for Hamilton Rating Scale of Depression scores compared to the baseline value.
...
...