An 19F Magnetic Resonance–Based In Vivo Assay of Solid Tumor Methotrexate Resistance: Proof of Principle

@article{Spees2005An1M,
  title={An 19F Magnetic Resonance–Based In Vivo Assay of Solid Tumor Methotrexate Resistance: Proof of Principle},
  author={W. Spees and T.P.F. Gade and G. Yang and W. Tong and W. Bornmann and R. Gorlick and J. Koutcher},
  journal={Clinical Cancer Research},
  year={2005},
  volume={11},
  pages={1454 - 1461}
}
Purpose: Studies in oncology have implicated multiple molecular mechanisms as contributors to intrinsic and acquired tumor resistance to antifolate therapy. Here we show the utility of an 19F-labeled methotrexate (FMTX) with 19F magnetic resonance to differentiate between sensitive and resistant tumors in vivo and thus predict therapeutic response. Experimental Design: Human sarcoma xenografts in nude mice were used in this study. The sarcoma cell lines chosen for this study (HT-1080, HS-16… Expand

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