An α3β4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons

@article{Park2006AnS,
  title={An α3β4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons},
  author={Kyu-Sang Park and Seung-Kyu Cha and Min-Jeong Kim and Dae-Ran Kim and Seong-Woo Jeong and Joong-Woo Lee and In Deok Kong},
  journal={Pfl{\"u}gers Archiv},
  year={2006},
  volume={452},
  pages={775-783}
}
We identified major subunits of the nicotinic acetylcholine receptor (nAChR) involved in excitatory postsynaptic potential and intracellular Ca2+ ([Ca2+]i) increase in the major pelvic ganglion (MPG) neurons of the male rat. ACh elicited fast inward currents in both sympathetic and parasympathetic MPG neurons. Mecamylamine, a selective antagonist for α3β4 nAChR, potently inhibited the ACh-induced currents in sympathetic and parasympathetic neurons (IC50; 0.53 and 0.22 μM, respectively… CONTINUE READING

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Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Modulation of N-type Ca2+ currents by A1-adenosine receptor activation in male rat pelvic ganglion neurons.

VIEW 4 EXCERPTS

International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits

  • RJ Lukas, J Changeux, +15 authors S Wonnacott
  • Pharmacol Rev 51(2):397–401
  • 1999
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Pharmacological properties of nicotinic acetylcholine receptors expressed by guinea pig small intestinal myenteric neurons.

VIEW 2 EXCERPTS