An α-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-κB in rats with TNBS-induced colitis.

@article{Hassan2010AnA,
  title={An α-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-κB in rats with TNBS-induced colitis.},
  author={Aktham Hassan and Ayman Yousif Ibrahim and Khaly Mbodji and Mo{\"i}se Co{\"e}ffier and Fr{\'e}d{\'e}ric Ziegler and Fr{\'e}d{\'e}ric Bounoure and Jean-Michel Chardigny and Mohamed Skiba and Guillaume Savoye and Pierre D{\'e}chelotte and Rachel Marion-Letellier},
  journal={The Journal of nutrition},
  year={2010},
  volume={140 10},
  pages={1714-21}
}
We have previously shown that α-linolenic acid (ALA), a (n-3) PUFA exerts in vitro antiinflammatory effects in the intestine. In this study, we aimed to evaluate its effect on inflammatory and oxidative stress in a colitis model. Colitis was induced in 2 groups at d 0 by intrarectal injection of 2-4-6-trinitrobenzen sulfonic acid (TNBS), whereas the control group received the vehicle. Rats we fed 450 mg . kg(-1) . d(-1) of ALA (TNBS+ALA) while the other colitic group (TNBS) and the control… CONTINUE READING