An 'injury-time integral' model for extrapolating from acute to chronic effects of phosgene.

@article{Hatch2001AnI,
  title={An 'injury-time integral' model for extrapolating from acute to chronic effects of phosgene.},
  author={Gary E. Hatch and Urmila P Kodavanti and Kay M Crissman and Ralph Slade and Daniel L. Costa},
  journal={Toxicology and industrial health},
  year={2001},
  volume={17 5-10},
  pages={285-93}
}
The present study compares acute and subchronic episodic exposures to phosgene to test the applicability of the 'concentrationxtime' (CxT) product as a measure of exposure dose, and to relate acute toxicity and adaptive responses to chronic toxicity. Rats (male Fischer 344) were exposed (six hours/day) to air or 0.1, 0.2, 0.5 and 1.0 ppm of phosgene one time or on a repeated regimen for up to 12 weeks as follows: 0.1 ppm (five days/week), 0.2 ppm (five days/week), 0.5 ppm (two days/week), or 1… CONTINUE READING

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