Amyotrophic lateral sclerosis.

  title={Amyotrophic lateral sclerosis.},
  author={J. Jefferson P. Perry and David S. Shin and John A. Tainer},
  journal={Advances in experimental medicine and biology},
Amyotrophic lateral sclerosis (ALS) is a common neurological disorder that results in loss of motor neurons, leading to a rapidly progressive form of muscle paralysis that is fatal. There is no available cure and current therapies only provide minimal benefit at best. The disease is predominantly sporadic and until very recently only the Cu,Zn superoxide dismutase (Cu,ZnSOD), which is involved in a small number of sporadic cases and a larger component of familial ones, have been analyzed in any… CONTINUE READING
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