Amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Hohara focus of the Kii Peninsula: A multiple proteinopathy?

Abstract

The high incidence of amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC) has been previously known in the Kii Peninsula of Japan and in Guam. Recently, the accumulation of various proteins, such as tau, trans-activation response DNA binding protein 43 kDa (TDP-43), and alpha-synuclein (αSyn), was reported in the brains of patients… (More)
DOI: 10.1111/neup.12434

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Cite this paper

@article{Mimuro2017AmyotrophicLS, title={Amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Hohara focus of the Kii Peninsula: A multiple proteinopathy?}, author={Maya Mimuro and Mari Yoshida and Shigeki Kuzuhara and Yasumasa Kokubo}, journal={Neuropathology : official journal of the Japanese Society of Neuropathology}, year={2017} }