Amyotrophic lateral sclerosis

@article{Hardiman2017AmyotrophicLS,
  title={Amyotrophic lateral sclerosis},
  author={O. Hardiman and A. Al-Chalabi and A. Chi{\`o} and E. M. Corr and G. Logroscino and W. Robberecht and P. Shaw and Z. Simmons and L. Berg},
  journal={Nature Reviews Disease Primers},
  year={2017},
  volume={3}
}
  • O. Hardiman, A. Al-Chalabi, +6 authors L. Berg
  • Published 2017
  • Medicine
  • Nature Reviews Disease Primers
  • Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and eventual paralysis. Until recently, ALS was classified primarily within the neuromuscular domain, although new imaging and neuropathological data have indicated the involvement of the non-motor neuraxis in disease pathology. In most patients, the mechanisms underlying the development of ALS are poorly understood… CONTINUE READING
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    References

    SHOWING 1-10 OF 257 REFERENCES
    Hereditary motor neuropathies and motor neuron diseases: which is which
    • C. O. Hanemann, A. Ludolph
    • Medicine
    • Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
    • 2002
    • 10
    Energy metabolism in amyotrophic lateral sclerosis
    • 341
    State of play in amyotrophic lateral sclerosis genetics
    • 980
    • PDF
    Mutations of optineurin in amyotrophic lateral sclerosis
    • 958