Amyotrophic lateral sclerosis

  title={Amyotrophic lateral sclerosis},
  author={O. Hardiman and A. Al-Chalabi and A. Chi{\`o} and E. M. Corr and G. Logroscino and W. Robberecht and P. Shaw and Z. Simmons and L. Berg},
  journal={Nature Reviews Disease Primers},
  • O. Hardiman, A. Al-Chalabi, +6 authors L. Berg
  • Published 2017
  • Medicine
  • Nature Reviews Disease Primers
  • Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and eventual paralysis. Until recently, ALS was classified primarily within the neuromuscular domain, although new imaging and neuropathological data have indicated the involvement of the non-motor neuraxis in disease pathology. In most patients, the mechanisms underlying the development of ALS are poorly understood… CONTINUE READING
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