Amyotrophic lateral sclerosis

@article{Feldman2017AmyotrophicLS,
  title={Amyotrophic lateral sclerosis},
  author={Eva L. Feldman and Stephen A. Goutman and Susanne Petri and Letizia Mazzini and Masha Georges Savelieff and Pamela J. Shaw and Gen Sobue},
  journal={Nature Reviews Disease Primers},
  year={2017},
  volume={3}
}
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized by the degeneration of both upper and lower motor neurons, which leads to muscle weakness and eventual paralysis. Until recently, ALS was classified primarily within the neuromuscular domain, although new imaging and neuropathological data have indicated the involvement of the non-motor neuraxis in disease pathology. In most patients, the mechanisms underlying the development of ALS are poorly understood… 

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References

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An overview of recently developed novel non-invasive electrophysiological techniques that may serve as biomarkers to assess UMN and LMN dysfunction in ALS patients is provided.

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A comprehensive review of recent work showing that there is a considerable overlap between CMT, MN, SMA, ALS and PLS should help improve understanding of the pathogenesis of motor neuron degeneration and may aid the research for urgently needed new treatment strategies.

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Amyotrophic lateral sclerosis is a lethal, progressive neurodegenerative disease characterized by loss of motor neurons, and cognitive dysfunction is seen in 20% to 50% of patients.

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