Amyotrophic lateral sclerosis
@article{Es2017AmyotrophicLS, title={Amyotrophic lateral sclerosis}, author={M. V. Es and O. Hardiman and A. Chi{\`o} and A. Al-Chalabi and L. Berg}, journal={The Lancet}, year={2017}, volume={390}, pages={2084-2098} }
Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in the brain and spinal cord. This neurodegenerative syndrome shares pathobiological features with frontotemporal dementia and, indeed, many patients show features of both diseases. Many different genes and pathophysiological processes contribute to the disease, and it will be necessary to understand this heterogeneity to find effective treatments. In this Seminar, we discuss clinical and diagnostic… CONTINUE READING
Supplemental Presentations
Paper Mentions
Interventional Clinical Trial
Given the role of adaptive immunity in ALS, the pathogenicity of some clostridial strains on
motorneurons, the putative role of cyanobacteria in ALS development, and the increasing… Expand
Conditions | Amyotrophic Lateral Sclerosis |
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Intervention | Biological |
Interventional Clinical Trial
The purpose of this research is to investigate the validity of a previous clinical trial
named EH301, which showed beneficial effects of anti-oxidant therapies in patients with… Expand
Conditions | Amyotrophic Lateral Sclerosis (ALS) |
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Intervention | Combination Product |
Observational Clinical Trial
BACKGROUND/RATIONALE: The paucity of biomarkers for the diagnosis and monitoring of patients
affected by Amyotrophic Lateral Sclerosis (ALS) is one of the greatest concerns in ALS… Expand
Conditions | Amyotrophic Lateral Sclerosis |
---|---|
Intervention | Procedure |
Blog Post
18 Citations
Novel therapeutic targets for amyotrophic lateral sclerosis
- Medicine
- Indian journal of pharmacology
- 2019
- 2
Parkinsonian traits in amyotrophic lateral sclerosis (ALS): a prospective population-based study
- Medicine
- Journal of Neurology
- 2019
- 2
Multi-Omics for Biomarker Discovery and Target Validation in Biofluids for Amyotrophic Lateral Sclerosis Diagnosis.
- Medicine
- Omics : a journal of integrative biology
- 2018
- 10
Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches
- Medicine
- The Lancet Neurology
- 2019
- 22
- PDF
Radial diffusivity as an imaging biomarker for early diagnosis of non-demented amyotrophic lateral sclerosis
- Medicine
- European Radiology
- 2018
- 4
ALS-Associated SOD1(G93A) Decreases SERCA Pump Levels and Increases Store-Operated Ca2+ Entry in Primary Spinal Cord Astrocytes from a Transgenic Mouse Model
- Chemistry, Medicine
- International journal of molecular sciences
- 2019
- 3
- PDF
Meta-analysis of the association between ZNF512B polymorphism rs2275294 and risk of amyotrophic lateral sclerosis
- Medicine
- Neurological Sciences
- 2018
- 3
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