Amyotrophic lateral sclerosis: moving towards a new classification system

@article{AlChalabi2016AmyotrophicLS,
  title={Amyotrophic lateral sclerosis: moving towards a new classification system},
  author={Ammar Al-Chalabi and Orla Hardiman and Matthew C. Kiernan and Adriano Chi{\`o} and Benjamin Rix-Brooks and Leonard H. Berg},
  journal={The Lancet Neurology},
  year={2016},
  volume={15},
  pages={1182-1194}
}
Amyotrophic lateral sclerosis is a progressive adult-onset neurodegenerative disease that primarily affects upper and lower motor neurons, but also frontotemporal and other regions of the brain. The extent to which each neuronal population is affected varies between individuals. The subsequent patterns of disease progression form the basis of diagnostic criteria and phenotypic classification systems, with considerable overlap in the clinical terms used. This overlap can lead to confusion… 
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