Amyotrophic lateral sclerosis: moving towards a new classification system

  title={Amyotrophic lateral sclerosis: moving towards a new classification system},
  author={A. Al-Chalabi and O. Hardiman and M. Kiernan and A. Chi{\`o} and L. Berg},
  journal={The Lancet Neurology},
  • A. Al-Chalabi, O. Hardiman, +2 authors L. Berg
  • Published 2016
  • Medicine
  • The Lancet Neurology
  • Amyotrophic lateral sclerosis is a progressive adult-onset neurodegenerative disease that primarily affects upper and lower motor neurons, but also frontotemporal and other regions of the brain. The extent to which each neuronal population is affected varies between individuals. The subsequent patterns of disease progression form the basis of diagnostic criteria and phenotypic classification systems, with considerable overlap in the clinical terms used. This overlap can lead to confusion… CONTINUE READING
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