Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders

@article{Hof2004AmyotrophicLS,
  title={Amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam: quantitative neuropathology, immunohistochemical analysis of neuronal vulnerability, and comparison with related neurodegenerative disorders},
  author={Patrick R. Hof and Esther A. Nimchinsky and Valérie Buée-Scherrer and Luc Bu{\'e}e and J. Nasrallah and Andreas F. Hottinger and Dushyant P. Purohit and Arthur J. Loerzel and John C.H. Steele and André Delacourte and Constantin Bouras and John H. Morrison and Daniel P. Perl},
  journal={Acta Neuropathologica},
  year={2004},
  volume={88},
  pages={397-404}
}
Amyotrophic lateral sclerosis/parkinsonism-dementia complex (lytico-bodig) is a chronic neurodegenerative disorder with high prevalence among the native Chamorro population of Guam. Neuropathological, biochemical, and immunohistochemical analyses were performed on a relatively large series of Guamanian cases and compared to Alzheimer's disease cases. Thioflavin S and antibodies to amyloid βA4 and tau proteins were used for analysis of pathological changes, and antibodies to the calcium-binding… Expand
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