Amyotrophic Lateral Sclerosis Genetic Studies

  title={Amyotrophic Lateral Sclerosis Genetic Studies},
  author={J. He and M. Mangelsdorf and D. Fan and P. Bartlett and M. Brown},
  journal={The Neuroscientist},
  pages={599 - 615}
  • J. He, M. Mangelsdorf, +2 authors M. Brown
  • Published 2015
  • Biology, Medicine
  • The Neuroscientist
  • Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of obscure etiology. Multiple genetic studies have been conducted to advance our understanding of the disease, employing a variety of techniques such as linkage mapping in families, to genome-wide association studies and sequencing based approaches such as whole exome sequencing and whole genome sequencing and a few epigenetic analyses. While major progress has been made, the majority of the genetic variation involved in ALS is… CONTINUE READING
    14 Citations

    Figures, Tables, and Topics from this paper.

    Clinical and genetic basis of familial amyotrophic lateral sclerosis.
    • 13
    • PDF
    A comprehensive review of amyotrophic lateral sclerosis
    • 249
    • PDF
    Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis.
    • 19
    Amyotrophic Lateral Sclerosis: A Neurodegenerative Motor Neuron Disease With Ocular Involvement
    The epidemiology of amyotrophic lateral sclerosis.
    • 110


    Familial amyotrophic lateral sclerosis, a historical perspective
    • T. Siddique, S. Ajroud-Driss
    • Medicine
    • Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology
    • 2011
    • 40
    Exome sequencing to identify de novo mutations in sporadic ALS trios
    • 119
    • PDF
    A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
    • 123
    • PDF
    An estimate of amyotrophic lateral sclerosis heritability using twin data
    • 219
    • PDF