Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies.

@article{Lashuel2009AmyloidsGG,
  title={Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies.},
  author={Hilal A Lashuel and Rohit V. Pappu},
  journal={Chembiochem : a European journal of chemical biology},
  year={2009},
  volume={10 12},
  pages={1951-4}
}
Protein misfolding is the primary cause of several systemic and neurodegenerative diseases 2] and a major challenge in the development of protein-based therapeutics, Figure 1 top. In misfolding diseases such as cystic fibrosis and a1-antitrypsin deficiency, degradation and/or mistrafficking of specific proteins causes loss of protein function. A second… CONTINUE READING