Amyloidosis and bleeding: pathophysiology, diagnosis, and therapy.

  title={Amyloidosis and bleeding: pathophysiology, diagnosis, and therapy.},
  author={Christoph Sucker and Gerd Ruediger Hetzel and Bernd Grabensee and Marcus Stockschlaeder and Ruediger Eberhard Scharf},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  volume={47 6},
Amyloid diseases can be associated with potentially life-threatening hemorrhage. Pathogenetic factors contributing to the abnormal bleeding tendency in this setting are heterogeneous and depend on the type of amyloidosis and pattern of organ involvement. In patients with light-chain (AL) amyloidosis, acquired hemostatic abnormalities, including coagulation factor deficiencies, hyperfibrinolysis, and platelet dysfunction, can be regarded as the most important pathogenetic factors. In patients… CONTINUE READING
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