Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.

@article{Saftig1996AmyloidogenicPO,
  title={Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D.},
  author={Paul Saftig and Christoph Peters and Kurt von Figura and Katleen Craessaerts and Fred van Leuven and Bart De Strooper},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 44},
  pages={27241-4}
}
betaA4-Amyloid peptide, the main component of the amyloid plaques in the brain of Alzheimer's disease patients is produced from amyloid precursor protein (APP) by proteolytical processing. Several lines of evidence suggest a direct role for cathepsin D, the major endosomal/lysosomal aspartic endopeptidase, in betaA4-amyloid peptide generation. Here we tested this hypothesis using primary cultures of hippocampal neurons derived from cathepsin D-deficient (knock out) mice and expressing wild-type… CONTINUE READING