Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue.

@article{Lavatelli2008AmyloidogenicAA,
  title={Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue.},
  author={Francesca Lavatelli and David Perlman and Brian Spencer and Tatiana B. Prokaeva and M E Mccomb and Roger Th{\'e}berge and Lawreen H Connors and Vittorio Bellotti and David C. Seldin and Giampaolo Merlini and Martha Skinner and Catherine E. Costello},
  journal={Molecular & cellular proteomics : MCP},
  year={2008},
  volume={7 8},
  pages={1570-83}
}
In systemic amyloidoses, widespread deposition of protein as amyloid causes severe organ dysfunction. It is necessary to discriminate among the different forms of amyloid to design an appropriate therapeutic strategy. We developed a proteomics methodology utilizing two-dimensional polyacrylamide gel electrophoresis followed by matrix-assisted laser desorption/ionization mass spectrometry and peptide mass fingerprinting to directly characterize amyloid deposits in abdominal subcutaneous fat… CONTINUE READING