Amyloidogenic Regions and Interaction Surfaces Overlap in Globular Proteins Related to Conformational Diseases

@inproceedings{Castillo2009AmyloidogenicRA,
  title={Amyloidogenic Regions and Interaction Surfaces Overlap in Globular Proteins Related to Conformational Diseases},
  author={Virginia Castillo and Salvador Ventura},
  booktitle={PLoS Computational Biology},
  year={2009}
}
Protein aggregation underlies a wide range of human disorders. The polypeptides involved in these pathologies might be intrinsically unstructured or display a defined 3D-structure. Little is known about how globular proteins aggregate into toxic assemblies under physiological conditions, where they display an initially folded conformation. Protein aggregation is, however, always initiated by the establishment of anomalous protein-protein interactions. Therefore, in the present work, we have… CONTINUE READING
23 Citations
95 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 95 references

Similar Papers

Loading similar papers…