Amyloidogenesis of proteolytic fragments of human elastin

  title={Amyloidogenesis of proteolytic fragments of human elastin},
  author={Brigida Bochicchio and Antonietta Pepe and Florian Delaunay and Marina Lorusso and St{\'e}phanie Baud and Manuel Dauchez},
Some polypeptides encoded by the C-terminal region of human tropoelastin gene have been demonstrated to be amyloidogenic in vitro. The biological relevance of this finding is still under investigation given that only limited evidence concerning the involvement of elastin in amyloidosis exists. Recent studies identified, by mass spectrometry, several elastin fragments produced from the cleavages made by some elastases in human elastin substrate. Some of these fragments are contained into the… CONTINUE READING