Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice.

@article{Dickey2004AmyloidSI,
  title={Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice.},
  author={Chad A Dickey and Marcia N Gordon and Jerimiah E Mason and Nedda J Wilson and David M. Diamond and John F. Guzowski and David Morgan},
  journal={Journal of neurochemistry},
  year={2004},
  volume={88 2},
  pages={434-42}
}
Mice transgenic for mutated forms of the amyloid precursor protein (APP) plus presenilin-1 (PS1) genes (APP + PS1 mice) gradually develop memory deficits which correlate with the extent of amyloid deposition. The expression of several immediate-early genes (IEGs: Arc, Nur77 and Zif268) and several other plasticity-related genes (GluR1, CaMKIIalpha and Na-K- ATPase alphaIII) critical for learning and memory was normal in young APP + PS1 mice preceding amyloid deposition, but declined as mice… CONTINUE READING