Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein (APP) gene.

@article{Racchi1999AmyloidPP,
  title={Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein (APP) gene.},
  author={Marco Racchi and Janet A. Johnston and Fiona Flood and Richard F. Cowburn and Stefano Govoni},
  journal={The Biochemical journal},
  year={1999},
  volume={338 ( Pt 3)},
  pages={777-82}
}
Protein kinase C (PKC)-activated modulation of amyloid precursor protein (APP) metabolism has been investigated in natural models of altered APP expression due to the presence of one, two or three copies of the APP gene. We show that levels of APP present in human skin fibroblasts strongly influence the effect of PKC activation of soluble APP (sAPP) release… CONTINUE READING