Amyloid precursor protein interacts with notch receptors.

  title={Amyloid precursor protein interacts with notch receptors.},
  author={Sun Young Oh and Aviva Ellenstein and C. Chen and Jason D Hinman and Eric A Berg and Catherine E. Costello and Rina Yamin and Rachael Lee Neve and Carmela R. Abraham},
  journal={Journal of neuroscience research},
  volume={82 1},
The amyloid precursor protein (APP) must fulfill important roles based on its sequence conservation from fly to human. Although multiple functions for APP have been proposed, the best-known role for this protein is as the precursor of Abeta peptide, a neurotoxic 39-43-amino acid peptide crucial to the pathogenesis of Alzheimer's disease. To investigate additional roles for APP with an eye toward understanding the molecular basis of the pleiotropic effects ascribed to APP, we isolated proteins… CONTINUE READING


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