Amyloid precursor protein (<ce:italic>APP</ce:italic>) A673T mutation in the elderly Finnish population

@article{Kero2013AmyloidPP,
  title={Amyloid precursor protein (<ce:italic>APP</ce:italic>) A673T mutation in the elderly Finnish population},
  author={Mia Kero and Anders Paetau and Tuomo M. Polvikoski and Maarit Tanskanen and Pentti J. Tienari},
  journal={Neurobiology of Aging},
  year={2013},
  volume={34},
  pages={1518.e1-1518.e3}
}
Pathogenic mutations of the APP gene, leading to early-onset Alzheimer's disease (AD) have been known for more than 20 years. Recently, it was discovered that APP mutations might also be protective. A rare variant A673T reportedly protects against AD and age-related cognitive impairment and might functionally inhibit proteolytic cleavage at the β-secretase site of APP. We sequenced APP exon 16 in a population-based sample of 515 Finnish subjects aged 85 or older. Neuropathologic data were… CONTINUE READING
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