Amyloid plaque core protein in Alzheimer disease and Down syndrome.

  title={Amyloid plaque core protein in Alzheimer disease and Down syndrome.},
  author={Colin L. Masters and G E Simms and N A Weinman and Gerhard Multhaup and Barbara L. McDonald and Konrad Beyreuther},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={82 12},
We have purified and characterized the cerebral amyloid protein that forms the plaque core in Alzheimer disease and in aged individuals with Down syndrome. The protein consists of multimeric aggregates of a polypeptide of about 40 residues (4 kDa). The amino acid composition, molecular mass, and NH2-terminal sequence of this amyloid protein are almost identical to those described for the amyloid deposited in the congophilic angiopathy of Alzheimer disease and Down syndrome, but the plaque core… CONTINUE READING
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