Amyloid oligomers in diabetic and nondiabetic human pancreas.

@article{Zhao2009AmyloidOI,
  title={Amyloid oligomers in diabetic and nondiabetic human pancreas.},
  author={Hai-Lu Zhao and Yun Kang Sui and Jing Guan and Lan He and Xue-mei Gu and Harriet Kt Wong and Larry S. Baum and Fernand M. M. Lai and Peter C. Tong and Juliana C. Chan},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2009},
  volume={153 1},
  pages={
          24-32
        }
}
The amyloid hypothesis of type 2 diabetes mellitus postulates that elevated levels of normally expressed monomeric proteins of human islet amyloid polypeptide (hIAPP) trigger oligomerization that independently causes fibril formation and disease progression. The aim of this study was to demonstrate the existence of amyloid oligomers in human pancreatic islets. Human pancreas tissues were obtained at autopsy of 8 nondiabetic control subjects (mean age = 75.8 +/- 11.7 years, 4 males), 8 type 2… CONTINUE READING
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