Amyloid inhibitors enhance survival of cultured human islets.

Abstract

BACKGROUND Amyloid fibrils created by misfolding and aggregation of proteins are a major pathological feature in a variety of degenerative diseases. Therapeutic approaches including amyloid vaccines and anti-aggregation compounds in models of amyloidosis point to an important role for amyloid in disease pathogenesis. Amyloid deposits derived from the beta… (More)
DOI: 10.1016/j.bbagen.2009.02.013

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