Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets

@article{Udayasankar2008AmyloidFR,
  title={Amyloid formation results in recurrence of hyperglycaemia following transplantation of human IAPP transgenic mouse islets},
  author={Jayalakshmi Udayasankar and Keiichi Kodama and Rebecca L Hull and Sakeneh Zraika and Kathryn Aston-Mourney and Shoba L Subramanian and Jenny Tong and Mirjam V. Faulenbach and Josep Vidal and Steven E Kahn},
  journal={Diabetologia},
  year={2008},
  volume={52},
  pages={145-153}
}
Islet transplantation is a potential cure for diabetes; however, rates of graft failure remain high. The aim of the present study was to determine whether amyloid deposition is associated with reduced beta cell volume in islet grafts and the recurrence of hyperglycaemia following islet transplantation. We transplanted a streptozotocin-induced mouse model of diabetes with 100 islets from human IAPP (which encodes islet amyloid polypeptide) transgenic mice that have the propensity to form islet… CONTINUE READING

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Amyloid formation in human islets is enhanced by heparin and inhibited by heparinase.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2015
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JW Hoppener, JS Verbeek, mice de Koning EJ et al Chronic overproduction of islet transgenic
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