Amyloid formation by globular proteins under native conditions.

  title={Amyloid formation by globular proteins under native conditions.},
  author={Fabrizio Chiti and Christopher M. Dobson},
  journal={Nature chemical biology},
  volume={5 1},
The conversion of proteins from their soluble states into well-organized fibrillar aggregates is associated with a wide range of pathological conditions, including neurodegenerative diseases and systemic amyloidoses. In this review, we discuss the mechanism of aggregation of globular proteins under conditions in which they are initially folded. Although a conformational change of the native state is generally necessary to initiate aggregation, we show that a transition across the major energy… CONTINUE READING
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