Amyloid fibrils from the viewpoint of protein folding

  title={Amyloid fibrils from the viewpoint of protein folding},
  author={Satoshi Ohnishi and K. Takano},
  journal={Cellular and Molecular Life Sciences CMLS},
  • S. Ohnishi, K. Takano
  • Published 1 March 2004
  • Biology, Chemistry
  • Cellular and Molecular Life Sciences CMLS
In amyloid related diseases, proteins form fibrillar aggregates with highly ordered β-sheet structure regardless of their native conformations. Formation of such amyloid fibrils can be reproducible in vitro using isolated proteins/peptides, suggesting that amyloid fibril formation takes place as a result of protein conformational change. In vitro studies revealed that perturbation of the native structure is important for the fibril formation, and it is suggested that the mechanisms of amyloid… 

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