Amyloid-fibril formation. Proposed mechanisms and relevance to conformational disease.

  title={Amyloid-fibril formation. Proposed mechanisms and relevance to conformational disease.},
  author={Eva Žerovnik},
  journal={European journal of biochemistry},
  volume={269 14},
The phenomenon of the transformation of proteins into amyloid-fibrils is of interest, firstly, because it is closely connected to the so-called conformational diseases, many of which are hitherto incurable, and secondly, because it remains to be explained in physical terms (energetically and structurally). The process leads to fibrous aggregates in the form of extracellular amyloid plaques, neuro-fibrillary tangles and other intracytoplasmic or intranuclear inclusions. In this review, basic… CONTINUE READING

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