Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.

@article{Brender2008AmyloidFF,
  title={Amyloid fiber formation and membrane disruption are separate processes localized in two distinct regions of IAPP, the type-2-diabetes-related peptide.},
  author={Jeffrey R. Brender and E Lyn Lee and Marchello A Cavitt and Ari A Gafni and Duncan G. Steel and Ayyalusamy Ramamoorthy},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 20},
  pages={6424-9}
}
Aggregation of Islet Amyloid Polypeptide (IAPP) has been implicated in the development of type II diabetes. Because IAPP is a highly amyloidogenic peptide, it has been suggested that the formation of IAPP amyloid fibers causes disruption of the cellular membrane and is responsible for the death of beta-cells during type II diabetes. Previous studies have shown that the N-terminal 1-19 region, rather than the amyloidogenic 20-29 region, is primarily responsible for the interaction of the IAPP… CONTINUE READING

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