Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?

@article{Ledesma2006AmyloidEI,
  title={Amyloid excess in Alzheimer's disease: what is cholesterol to be blamed for?},
  author={Mar{\'i}a Dolores Ledesma and Carlos G Dotti},
  journal={FEBS letters},
  year={2006},
  volume={580 23},
  pages={5525-32}
}
A link between alterations in cholesterol homeostasis and Alzheimer's disease (AD) is nowadays widely accepted. However, the molecular mechanism/s underlying such link remain unclear. Numerous experimental evidences support the view that changes in neuronal membrane cholesterol levels and/or subcellular distribution determine the aberrant accumulation of the amyloid peptide in the disease. Still, this view comes from rather contradictory data supporting the existence of either high or low brain… CONTINUE READING