Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

@article{Oddo2003AmyloidDP,
  title={Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.},
  author={Salvatore Oddo and Antonella Caccamo and Masashi Kitazawa and Bertrand P Tseng and Frank M Laferla},
  journal={Neurobiology of aging},
  year={2003},
  volume={24 8},
  pages={1063-70}
}
Amyloid-beta (Abeta) containing plaques and tau-laden neurofibrillary tangles are the defining neuropathological features of Alzheimer's disease (AD). To better mimic this neuropathology, we generated a novel triple transgenic model of AD (3xTg-AD) harboring three mutant genes: beta-amyloid precursor protein (betaAPPSwe), presenilin-1 (PS1M146V), and tauP301L. The 3xTg-AD mice progressively develop Abeta and tau pathology, with a temporal- and regional-specific profile that closely mimics their… CONTINUE READING
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