Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons

@article{Grtner2003AmyloidDI,
  title={Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons},
  author={Ulrich G{\"a}rtner and Martina K. Br{\"u}ckner and Sabine Krug and Stefanie Schmetsdorf and Matthias Staufenbiel and Thomas Arendt},
  journal={Acta Neuropathologica},
  year={2003},
  volume={106},
  pages={535-544}
}
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the intracellular accumulation of highly phosphorylated tau protein, the extracellular formation of amyloid plaques and a significant loss of neurons. Recent evidence suggests that neuronal death in AD involves an aborted attempt of cells to re-enter the cell cycle. To study the effect of amyloid deposits on cell cycle related events in vivo, the expression of cell cycle markers was examined by immunohistochemistry in… CONTINUE READING
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Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2006
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