Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).

@article{Broeckhoven1990AmyloidBP,
  title={Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).},
  author={Christine Van Broeckhoven and Joost Haan and Egbert Bakker and John Hardy and Wim Van Hul and Anita Wehnert and Maria Vegter-van der Vlis and Raymund Roos},
  journal={Science},
  year={1990},
  volume={248 4959},
  pages={1120-2}
}
Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form of cerebral amyloid angiopathy (CAA), is characterized by extensive amyloid deposition in the small leptomeningeal arteries and cortical arterioles, which lead to an early death of those afflicted in their fifth or sixth decade. Immunohistochemical and biochemical studies have indicated that the amyloid subunit in HCHWA-D is antigenically related to and homologous in sequence with the… CONTINUE READING
75 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

Similar Papers

Loading similar papers…