Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro.

@article{Gregori1995AmyloidBI,
  title={Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro.},
  author={Luisa Gregori and Christine Fuchs and Maria E Figueiredo-Pereira and William E. Van Nostrand and Dmitry Goldgaber},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 34},
  pages={19702-8}
}
Intraneuronal accumulation of ubiquitin conjugates in inclusion bodies and neurofibrillary tangles is a pathological feature of neurodegenerative disorders such as Alzheimer's disease and Down's syndrome and of normal aging of the brain. Amyloid beta-protein (A beta) and its precursor are found in neurofibrillary tangle-containing neurons. A beta is the major component of extracellular plaques. We showed that A beta acts as an inhibitor of the ubiquitin-dependent protein degradation in vitro… CONTINUE READING