Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold

@inproceedings{Grabrucker2011AmyloidBP,
  title={Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold},
  author={Andreas M Grabrucker and Michael Schmei\sser and Patrick T. Udvardi and Magali H Arons and Michael P Sch{\"o}n and Nathaniel S Woodling and Katrin I. Andreasson and Patrick R. Hof and Joseph D. Buxbaum and Craig C. Garner and Tobias Maria Boeckers},
  booktitle={Molecular Neurodegeneration},
  year={2011}
}
Memory deficits in Alzheimer's disease (AD) manifest together with the loss of synapses caused by the disruption of the postsynaptic density (PSD), a network of scaffold proteins located in dendritic spines. However, the underlying molecular mechanisms remain elusive. Since it was shown that ProSAP2/Shank3 scaffold assembly within the PSD is Zn2+-dependent and that the amyloid beta protein (Aβ) is able to bind Zn2+, we hypothesize that sequestration of Zn2+ ions by Aβ contributes to ProSAP… CONTINUE READING
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