Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.

  title={Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates.},
  author={Dominic M Walsh and Dean M. Hartley and Yoshihumi Kusumoto and Youcef Fezoui and Margaret A M Condron and Aleksey Lomakin and George B. Benedek and Dennis J Selkoe and David B Teplow},
  journal={The Journal of biological chemistry},
  volume={274 36},
Alzheimer's disease is characterized by extensive cerebral amyloid deposition. Amyloid deposits associated with damaged neuropil and blood vessels contain abundant fibrils formed by the amyloid beta-protein (Abeta). Fibrils, both in vitro and in vivo, are neurotoxic. For this reason, substantial effort has been expended to develop therapeutic approaches to control Abeta production and amyloidogenesis. Achievement of the latter goal is facilitated by a rigorous mechanistic understanding of the… CONTINUE READING
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