• Biology, Medicine
  • Published in
    The American journal of…
    1996

Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.

@article{Fukumoto1996AmyloidBP,
  title={Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.},
  author={Hiroaki Fukumoto and Asano Asami-Odaka and Noriko Suzuki and H Shimada and Yasuo Ihara and Takeshi Iwatsubo},
  journal={The American journal of pathology},
  year={1996},
  volume={148 1},
  pages={
          259-65
        }
}
Two distinct species of amyloid beta protein (A beta) with different C-termini, A beta 42(43) and A beta 40, are deposited in senile plaques (SP) of Alzheimer's disease (AD), with the former being far predominant. To investigate whether A beta 42(43) also predominates over A beta 40 in normal aging, we examined by immunocytochemistry the C-termini of A beta in SP in the brains of non-demented aged individuals and compared the results with those in AD. Virtually all SP were A beta 42(43… CONTINUE READING

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