• Medicine
  • Published in Neurochemistry international 2001

Amyloid beta protein activates PKC-delta and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia.

@article{Nakai2001AmyloidBP,
  title={Amyloid beta protein activates PKC-delta and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia.},
  author={Masamichi Nakai and Satoshi Tanimukai and Keiko Yagi and Naoaki Saito and Taketoshi Taniguchi and A Terashima and Toshio Kawamata and H. Yamamoto and Kenji Fukunaga and Eishichi Miyamoto and Chikako Tanaka},
  journal={Neurochemistry international},
  year={2001},
  volume={38 7},
  pages={
          593-600
        }
}
The increased accumulation of activated microglia containing amyloid beta protein (Abeta) around senile plaques is a common pathological feature in subjects with Alzheimer's disease (AD). Much less is known, however, of intracellular signal transduction pathways for microglial activation in response to Abeta. We investigated intracellular signaling in response to Abeta stimulation in primary cultured rat microglia. We found that the kinase activity of PKC-delta but not that of PKC-alpha or… CONTINUE READING

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Amyloid beta oligomers induce impairment of neuronal insulin receptors.

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  • 2008