Amyloid beta protein-(1-42) forms calcium-permeable, Zn2+-sensitive channel.

  title={Amyloid beta protein-(1-42) forms calcium-permeable, Zn2+-sensitive channel.},
  author={Seung Keun Rhee and Arjan Pieter Quist and R. Jawahar Lal},
  journal={The Journal of biological chemistry},
  volume={273 22},
Amyloid beta protein (AbetaP) forms senile plaques in the brain of the patients with Alzheimer's disease. The early-onset AD has been correlated with an increased level of 42-residue AbetaP (AbetaP1-42). However, very little is known about the role of AbetaP1-42 in such pathology. We have examined the activity of AbetaP1-42 reconstituted in phospholipid vesicles. Vesicles reconstituted with AbetaP show strong immunofluorescence labeling with an antibody raised against an extracellular domain of… CONTINUE READING

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