Amyloid beta-protein, APOE genotype and head injury.

  title={Amyloid beta-protein, APOE genotype and head injury.},
  author={James A. R. Nicoll and Gareth W Roberts and David I. Graham},
  journal={Annals of the New York Academy of Sciences},
Deposition of amyloid beta-protein (A beta) in the brain plays a key role in the pathogenesis of Alzheimer's disease. Head injury is an epidemiological risk factor for Alzheimer's disease, and deposition of A beta occurs in approximately one third of individuals dying shortly after a severe head injury. Of the three common apolipoprotein E alleles (APOE-epsilon 2, epsilon 3, and epsilon 4) APOE-epsilon 4 allele is a strong risk factor for both sporadic and some familial cases of Alzheimer's… CONTINUE READING

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