Amyloid beta peptides with an additional cysteine residue can enhance immunogenicity and reduce the amyloid beta burden in an Alzheimer's disease mouse model.

Abstract

For the development of a safe vaccine for Alzheimer's disease (AD), we studied the immunogenicity of amyloid beta (Abeta) peptides without adjuvant. Addition of a cysteine residue (Cys) to Abeta peptides enhanced immunogenicity in mice compared to those without Cys. Vaccination with the Abeta-Cys peptides reduced Abeta deposits in AD model mice. From these… (More)
DOI: 10.1016/j.bbrc.2009.02.153

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Cite this paper

@article{Matsuda2009AmyloidBP, title={Amyloid beta peptides with an additional cysteine residue can enhance immunogenicity and reduce the amyloid beta burden in an Alzheimer's disease mouse model.}, author={Junichi Matsuda and Kazuyoshi Kaminaka and Chikateru Nozaki}, journal={Biochemical and biophysical research communications}, year={2009}, volume={382 1}, pages={149-52} }