Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation.

@article{Mark1997AmyloidBI,
  title={Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation.},
  author={Robert J. Mark and Zhen Pang and James W. Geddes and Koji Uchida and Mark P. Mattson},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 3},
  pages={1046-54}
}
A deficit in glucose uptake and a deposition of amyloid beta-peptide (A beta) each occur in vulnerable brain regions in Alzheimer's disease (AD). It is not known whether mechanistic links exist between A beta deposition and impaired glucose transport. We now report that A beta impairs glucose transport in cultured rat hippocampal and cortical neurons by a mechanism involving membrane lipid peroxidation. A beta impaired 3H-deoxy-glucose transport in a concentration-dependent manner and with a… CONTINUE READING
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Anticonvulsants attenuate amyloid b-peptide neurotoxicity and promote maintenance of calcium homeostasis

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