Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice.

@article{Dineley2010AmyloidbetaOI,
  title={Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice.},
  author={Kelly Tennyson Dineley and Rakez Kayed and Volker Neugebauer and Yu Fu and Wenru Zhang and Lindsay C Reese and Giulio Taglialatela},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 13},
  pages={2923-32}
}
Soluble oligomeric aggregates of the amyloid-beta (A beta) peptide are believed to be the most neurotoxic A beta species affecting the brain in Alzheimer disease (AD), a terminal neurodegenerative disorder involving severe cognitive decline underscored by initial synaptic dysfunction and later extensive neuronal death in the CNS. Recent evidence indicates that A beta oligomers are recruited at the synapse, oppose expression of long-term potentiation (LTP), perturb intracellular calcium balance… CONTINUE READING